A look at the professional and personal lives of the staff at New York's Knickerbocker Hospital during the early part of the twentieth century. Every day they must deal with lack of funding, personal conflicts, egotism, racial tensions, personal vices, drug addiction, affairs, closed minds, dated nigh-medieval medical techniques and them and their experimental new techniques being misunderstood by most, in order to keep the hospital going and give the ill the help they need. The pressure is enormous and leaves its mark on the souls of most of them.

Down and out rock star Dewey Finn gets fired from his band, and he faces a mountain of debts and depression. He takes a job as a 4th grade substitute teacher at an uptight private school where his attitude and hijinx have a powerful effect on his students. He also meets Zack, a 10-year-old guitar prodigy, who could help Dewey win a battle of the bands competition, which would solve his financial problems and put him back in the spotlight. Written by Anonymous